Dextran Sulfate Sodium
dextran sulfate so-salt from leuconostoc ssp.
CAS: 9011-18-1
Molecular Formula: (C6H7Na3O14S3)n
Dextran Sulfate Sodium - Names and Identifiers
Dextran Sulfate Sodium - Physico-chemical Properties
| Molecular Formula | (C6H7Na3O14S3)n |
| Molar Mass | 468.275 |
| Melting Point | Sulfur Content, 16.0-20.0% |
| Water Solubility | Soluble in water. |
| Solubility | H2O: 100mg/mL |
| Appearance | powder |
| Color | White to off-white |
| Merck | 2951 |
| PH | pH(50g/l, 25℃）4.5～8.0 |
| Storage Condition | room temp |
| MDL | MFCD00081551 |
| Physical and Chemical Properties | Sugar anhydride ester is a light yellow powder; it is hygroscopic. Soluble in water, insoluble in ethanol and ether. The 6% aqueous solution is colorless or light yellow clear solution with a pH of 5-7.5. Sugar anhydride esters were initially used as plasma substitutes and later used to lower blood lipids. It can improve the vitality of the fibrinolytic system, prevent the deposition of fibrin and anticoagulation; it can effectively improve the activity of lipoproteinase, promote the release of esterase into the blood, decompose chylomicrons, and clarify blood lipids; reduce serum total cholesterol content, Relieve the affinity of β-lipoprotein and fibrin to the blood vessel wall; it can antagonize the effect of hyaluronic acid enzyme and reduce the normal metabolism of the blood vessel wall. Sugar anhydride ester tablets are enteric sugar-coated sugar-coated tablets. After removing the sugar coating, the heart of the tablets is light yellow. |
| Use | Hypolipidemic and antiatherosclerotic agents |
Dextran Sulfate Sodium - Risk and Safety
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 2 |
| RTECS | HH9290000 |
| FLUKA BRAND F CODES | 3-10 |
| TSCA | Yes |
| HS Code | 39139000 |
Dextran Sulfate Sodium - Reference
| Reference Show more | 1. Zhao Dangsheng, Jin, Mei, Li, Lin, Feng Chuan, Xu Chunying, Wang Fengyi. Effect of Shenbai mixture on ulcerative colitis model mice and expression of IL-10 and TNF-α [J]. Research in Traditional Chinese Medicine, 2012, 25(03):64-66. 2. Study on preparation and anti-platelet aggregation activity of low molecular weight fucoidan from Laminaria japonica [J]. China Marine Medicine, 2017, 25 (01):19-26. 3. Li, Ai-li, et al. "Effect of 2 '-fucosiclactose supplement on essential flora." International Journal 110 (2020): 104797.https://doi.org/10.1016/j.idairyj.2020.104797 4. Yuan, Yongkai, et al. "Fabrication and characterization of zein nanoparticles by dextran sulfate coating as vehicles for delivery of curcumin." International journal of biological macromolecules 151 (2020): 1074-1083.https://doi.org/10.1016/j.ijbiomac.2019 5. Dou, Bo, et al. "Anti-inflammation of Erianin in dextran sulphate sodium-induced ulcerative colitis mice model via collaborative regulation of TLR4 and STAT3." Chemico-biological interactions 324 (2020): 109089.https://doi.org/10.1016/j.cbi.2020.109089 6. [IF=1.785] Chong Meng et al."A modified immunofluorescence in situ hybridization method to detect long non‑coding RNAs and proteins in frozen spinal cord sections."Exp Ther Med. 2018 Jun;15(6):4623-4628 7. [IF=6.543] Zhou Lin et al."Administration of Nrf-2-Modified Hair-Follicle MSCs Ameliorates DSS-Induced Ulcerative Colitis in Rats."Oxid Med Cell Longev. 2021;2021:9930187 8. [IF=5.914] Haoan Zhao et al."Honey Polyphenols Ameliorate DSS-Induced Ulcerative Colitis via Modulating Gut Microbiota in Rats."Mol Nutr Food Res. 2019 Dec;63(23):1900638 9. [IF=5.34] Mu-xia Li et al."Huangqin decoction ameliorates DSS-induced ulcerative colitis: Role of gut microbiota and amino acid metabolism, mTOR pathway and intestinal epithelial barrier."Phytomedicine. 2022 Jun;100:154052 10. [IF=6.953] Zewen Mei et al."Chitin derivatives ameliorate DSS-induced ulcerative colitis by changing gut microbiota and restoring intestinal barrier function."Int J Biol Macromol. 2022 Mar;202:375 11. [IF=6.953] Xue Liu et al."Structural characterization of a P-selectin and EGFR dual-targeting fucoidan from Sargassum fusiforme."Int J Biol Macromol. 2022 Feb;199:86 12. [IF=9.381] Siwen Wu et al."Dextran and peptide-based pH-sensitive hydrogel boosts healing process in multidrug-resistant bacteria-infected wounds."Carbohyd Polym. 2022 Feb;278:118994 |
Dextran Sulfate Sodium - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| biological activity | Dextran, A selective human immunodeficiency virus type 1 (HIV-1) inhibitor that inhibits virus adsorption into host cells. |
| Target | Value |
| Use | hypolipidemic drug. lipid-lowering and anti-atherosclerosis drugs. |
| production method | hydrolysis Dextran was added with water, heated and dissolved to 20% g/L(1 %), add hydrochloric acid to make 0.3%-0.4%, reflux hydrolysis 3H, slightly cold, with 10% g/L () NaOH solution neutralization to pH6-6.5, to obtain hydrolysis liquid. After cooling, adding 40% ethanol, standing at 30 ℃ for 24h, take the supernatant and vacuum concentrate to 1/4 of the original volume, add 70% ethanol, stand for 4-6h, spin dry, collect the precipitate, micro-molecular Dextran was obtained. The viscosity (η) was 0.03-0.04, and the yield was about 60%. Dextran [HCl, NaOH]→[3H, pH6-6.5] hydrolysate [ethanol] → micro molecular dextran esterification according to micro molecular dextran (m): pyridine (V): chlorosulfonic acid (V)= 1:6:1.48 ratio. Pyridine (or formamide instead) is put into the reaction tank, chlorosulfonic acid is added dropwise under stirring at 25 ℃, heated to 45-65 ℃, and micro-molecular dextran powder is added for 2.5-4H, the mixture was allowed to stand and layered, and pyridine in the upper layer was poured to obtain a paste-like esterified product. Micro-molecular dextran [pyridine, chlorosulfonic acid] →[45-65 ℃, 2.5-4H] paste-like esterification product (dextran Ester pyridine sulfur trioxide double salt) neutralization, drying, stirring and cooling the paste-like esterification product, add proper amount of water at about 30 ℃, neutralize to pH10-11 with 40% g/L () NaOH, add proper amount of water and ethanol to the lower liquid to make its mass concentration reach 455g/L(45.5%), keep the temperature at 37 ℃, stir and wash for 30min, stand still, separate the lower liquid, the washing was repeated twice as described above. Sugar anhydride Ester sodium solution. Then add suitable amount of water and medicinal activated carbon, decolorize at 50 ℃, press filtration, add suitable amount of water and ethanol to the filtrate, make the ethanol reach 47.5%, keep the temperature at 37 ℃ and stir for 30min, stand still, separate the lower liquid, the lower liquid was decanted with ethanol, dehydrated, and dried at 50 ° C. To obtain sodium sugar anhydride ester. The total yield of dextran was 54%. Paste esterified [water, NaOH]→[30 ℃, pH10-11] lower liquid [ethanol] → sodium glyoxylate solution [water, activated carbon] → filtrate [ethanol] →[37 ℃, 30min] Sugar anhydride Ester sodium preparation according to the requirements of tablets made of sugar anhydride Ester sodium enteric coated tablets of sugar anhydride Ester sodium-sugar anhydride Ester sodium tablets. |
Last Update：2024-04-09 21:11:58
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